DeCS

Descriptor English:

Neurotransmitter Uptake Inhibitors

Descriptor Spanish:

Inhibidores de la Captación de Neurotransmisores

Spanish from Spain

Descriptor	inhibidores de la captación de neurotransmisores
Entry term(s)	inhibidor de la captación de neurotransmisores inhibidor de la recaptación de neurotransmisores inhibidores de la captación de transmisores neuronales inhibidores de la recaptación de neurotransmisores
Scope note:	Fármacos que inhiben el transporte de neurotransmisores hacia el interior de las terminales axónicas o hacia las vesículas de almacenamiento que están en las terminales. En el caso de muchos transmisores, la captación determina su periodo de acción, de modo que al inhibir la captación se prolonga la actividad del transmisor. El bloqueo de la captación puede también reducir los depósitos disponibles del trasmiso. Muchos fármacos importantes desde el punto de vista clínico son inhibidores de la captación, aunque a menudo son las reacciones indirectas sobre el cerebro, más que el propio bloqueo agudo de la captación, las responsables de los efectos terapéuticos.

Descriptor Portuguese:

Inibidores da Captação de Neurotransmissores

Descriptor French:

Inhibiteurs de la capture des neurotransmetteurs

Entry term(s):

Inhibitors, Neurotransmitter Reuptake
Inhibitors, Neurotransmitter Uptake
Neurotransmitter Reuptake Inhibitors
Reuptake Inhibitors, Neurotransmitter
Transmitter Uptake Inhibitors, Neuronal
Uptake Inhibitors, Neurotransmitter

Tree number(s):

D27.505.519.562.437
D27.505.519.625.600
D27.505.696.577.600

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D014179

Scope note:

Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.

Annotation:

general or unspecified; prefer specific groups or specific drugs; coordinate with specific neurotransmitters /physiol

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine

Previous Indexing:

Cytoplasmic Granules (1966-1977)
Kinetics (1966-1984)
Nerve Endings (1966-1973)
Synapses (1966-1971)
Synaptic Vesicles (1972-1973)
Synaptosomes (1974-1984)

Public MeSH Note:

93; was TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92; NEUROTRANSMITTER UPTAKE INHIBITORS, INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER were see TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92

Online Note:

use NEUROTRANSMITTER UPTAKE INHIBITORS to search TRANSMITTER UPTAKE INHIBITORS, NEURONAL; INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER 1985-92

History Note:

93; WAS TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92; NEUROTRANSMITTER UPTAKE INHIBITORS, INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER were see TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92

Concept UI	M0021830
Scope note	Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
Preferred term	Neurotransmitter Uptake Inhibitors
Entry term(s)	Inhibitors, Neurotransmitter Reuptake Inhibitors, Neurotransmitter Uptake Neurotransmitter Reuptake Inhibitors Reuptake Inhibitors, Neurotransmitter Transmitter Uptake Inhibitors, Neuronal Uptake Inhibitors, Neurotransmitter

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